pure testosterone

Absorption and distribution Sustained release of felodipine tablets, coated tablets, leading to elongation phase and absorption of the drug provides a uniform concentration of felodipine in plasma for 24 hours. Felodipine is almost completely absorbed from the gastrointestinal tract. Bioavailability is independent of dose within the therapeutic range and is about 15%. 99% of felodipine is associated with blood proteins, primarily albumin. Metabolism and elimination Felodipine is completely metabolized by the liver and all its metabolites are inactive. The half-life of felodipine is 25 hours. With prolonged use of cumulation of felodipine does not occur. Pharmacokinetics in special groups of patents in elderly patients and in cases of liver function abnormalities felodipine plasma concentration is higher than that of younger patients. The pharmacokinetic pure testosterone performance of felodipine are not changed in patients with impaired renal function, including during hemodialysis. About 70% of the dose is excreted in the urine and the remainder in the faeces in the form of metabolites. In unaltered with urine output of less than 0.5% of the dose. Felodipine penetrates through the blood-placenta barrier and is excreted in breast milk.

 

Indications

  • Arterial hypertension
  • Stable angina (including Prinzmetal angina)

Contraindications

  • Hypersensitivity to the felodipine and other dihydropyridine derivatives
  • Unstable angina
  • Acute myocardial infarction, and within one month after myocardial infarction
  • Cardiogenic shock
  • Clinically significant aortic stenosis
  • Pregnancy and lactation
  • Chronic heart failure in a decompensation stage
  • Severe hypotension
  • Age 18 years (effectiveness and safety have been established)

Precautions
Hepatic and / or renal failure, aortic stenosis, labile blood pressure and heart failure after myocardial infarction

Dosage and administration
. The drug is best taken in the morning inside before a meal or after a light breakfast,
coated tablets, it is impossible to crack, divide or crush. Hypertension Adults (including elderly): The dosage is always determined individually. Therapy begins with a dose of 5 mg 1 time a day. If necessary, the dosage may be increased; usual maintenance dose is 5-10 mg 1 time a day. To determine the best individual dose, tablets containing 2.5 mg of felodipine. . In the elderly or patients with impaired hepatic function The recommended starting dosage is 2.5 mg 1 time a day, stable angina pectoris Adults: The dosage is always determined individually. The treatment starts with a dose of 5 mg 1 time per day, if necessary, can be increased to 10 mg dose one time per day. The maximum daily dose is 20 mg 1 time a day. The drug felodipine can be used in combination with beta-blockers, angiotensin-converting enzyme pure testosterone inhibitors or diuretics. Combination therapy usually increases the hypotensive effect of the drug. It is necessary to guard against the development of arterial hypotension. In patients with severe hepatic impairment therapeutic dose should be reduced. In patients with impaired renal function The pharmacokinetics of the drug were not significantly changed.

Side effects
As well as the application of other blockers “slow” calcium channels, the drug can cause facial flushing, headache, palpitations, dizziness and fatigue. These reactions are reversible and often occur early in treatment or increasing dose. Also, in a dose dependent peripheral edema may occur that result precapillary vasodilation. In patients with periodontitis gingival inflammation or swelling may occur easy gums.This can prevent the careful observance of oral hygiene.
The frequency of side effects caused by the following definitions: frequent (1/100 or more) are less common (1 / 1000-1 / 100), rare (1 / 10000-1 / 1000), very rare (less than 1/10000). Since the cardiovascular system : often – “tides” of blood to the skin of the face, accompanied by facial flushing, swelling of the ankles; less often – tachycardia, palpitations; rarely – a swoon; very rarely – extrasystole, marked reduction in blood pressure is accompanied by reflex tachycardia and worsening of angina, leukocytoclastic vasculitis. From the nervous system : often – headache; less often – paresthesia, vertigo. From the digestive system : less often – nausea, abdominal pain; rarely – vomiting; very rarely – increased activity of “liver” transaminases; rarely -giperplaziya gums, tongue mucous membrane, gingivitis. From the musculoskeletal system : rarely – arthralgia, myalgia. Allergic reactions : less often – skin rash, itching; rarely – urticaria; very rarely – angioneurotic edema of the lips or tongue, photosensitivity reaction. From the urinary system : very rarely – pure testosterone urination. Others : less often – fatigue; rare impotence / sexual dysfunction; very rare – fever, hyperglycemia. For the skin : rare urticaria, and itching. In single sluchayah- photosensitivity reaction, causal relationship has not been established : chest pain, face edema, flu-like symptoms, decrease blood pressure, myocardial infarction, syncope, angina, arrhythmia, premature beats, diarrhea, dry mouth, bloating, gynecomastia, anemia, arthralgia, back pain, myalgia, pain in the upper and lower extremities, depression, insomnia, anxiety, nervousness, drowsiness, irritability, sore throat, shortness of breath, bronchitis, flu, sinusitis, epistaxis, erythema, bruising, leukocytoclastic vasculitis, impaired vision, polyuria, dysuria.