test no ester

After ingestion rapidly test no ester absorbed from the gastrointestinal tract after the maximum concentration . Mean maximum concentration  after receiving 180 mg – about 494 ng / mL after administration of 120mg – 427 ng / ml. Relationship to plasma proteins – 60-70% (mainly albumin and alpha-1-glycoprotein). It does not cross the blood-brain barer. After the multiple administration – 14.4 hours in patients with moderate (41-80 Creatinine clearance ml / min) and severe (11-40 ml / min) of renal insufficiency T1 /. 2 is increased by 59 and 72% respectively; in patients on hemodialysis, T1 / 2 increased by 31%. Treated (5% of the dose) partial extrahepatic metabolism. Write mainly (80%) in the bile, 11% – by the kidneys unchanged.

 

Indications for use:

 

Seasonal allergic rhinitis, chronic urticaria.

 

Contraindications:

 

Hypersensitivity, pregnancy, lactation, children’s age (12 years).

Carefully:

Chronic renal failure. (The recommended daily dose in such patients 60 mg once daily).

 

Dosage and administration:

 

Inside.

In seasonal allergic rhinitis in adults and children over 12 years: 120 mg 1 time per day.

In chronic urticaria 1 to 180 mg test no ester once a day.

 

Side effect:

 

Headache, drowsiness, nausea, dizziness. Rarely (less than 1 case per 1,000 appointments): fatigue, insomnia, nervousness, sleep disorder. In some cases: skin rash, urticaria, pruritus, and other hypersensitivity reactions (angioedema, dyspnoea).

 

Overdose:

 

Symptoms: dizziness, drowsiness and dry mouth. In case of overdose it is recommended that a standard measures to remove from the gastrointestinal tract unabsorbed drug. Recommended symptomatic and supportive therapy. Hemodialysis is ineffective.

Interaction with other drugs:

In a joint application with erythromycin or ketoconazole fexofenadine plasma concentration increases by 2-3 times. Receiving aluminum – magnesium antacids or 15 minutes before a fexofenadine reduces the bioavailability of the latter (the time interval between their intake should be at least 2 h.). It does not interact with omeprazole, a drug metabolized by the liver.

 

Special instructions:

 

Before the drug test no ester may perform activities that require high concentration and speed of psychomotor reactions (except for people with non-standard reaction to drugs). Thus, before embarking on the execution of these works (vehicle driving, operating machinery) must first check the individual response to the drug.