test suspension results

Absorption and distribution Sustained release of felodipine tablets, coated tablets, leading to elongation phase and absorption of the drug provides a uniform concentration of felodipine in plasma for 24 hours. Felodipine is almost completely absorbed from the gastrointestinal tract. Bioavailability test suspension results does not depend on the dose within the therapeutic range and is about 15%. 99% of felodipine is associated with plasma proteins, primarily albumin. Metabolism and elimination Felodipine is completely metabolized by the liver and all its metabolites are inactive. The half-life of felodipine is 25 hours. With prolonged use of cumulation of felodipine does not occur. Pharmacokinetics in special patient groups In elderly patients and in cases of liver function abnormalities felodipine plasma concentration is higher than that of younger patients. The pharmacokinetic performance of felodipine are not changed in patients with impaired renal function, including during hemodialysis. About 70% of the dose is excreted in the urine and the remainder in the faeces in the form of metabolites. In unaltered with urine output of less than 0.5% of the dose. Felodipine penetrates the blood-brain barrier into the placenta and is excreted in breast milk.

Indications

  • Arterial hypertension
  • Stable angina (including Prinzmetal angina)

Contraindications

  • Hypersensitivity to the felodipine and other dihydropyridine derivatives series
  • Unstable angina
  • Acute myocardial infarction, and within one month after myocardial infarction
  • Cardiogenic shock
  • Clinically significant aortic stenosis
  • Pregnancy and lactation
  • Heart failure in decompensation test suspension results stage
  • Severe hypotension
  • Age 18 years (effectiveness and safety have been established)

Precautions: hepatic and / or renal failure.

Dosage and administration
. The drug is best taken in the morning inside before a meal or after a light breakfast,
coated tablets, it is impossible to crack, divide or crush. Hypertension Adults (including elderly): The dosage is always determined individually. Therapy begins with a dose of 5 mg 1 time a day. If necessary, the dosage may be increased; usual maintenance dose is 5-10 mg 1 time a day. To determine the best individual dose, tablets containing 2.5 mg of felodipine. . In the elderly or patients with impaired hepatic function The recommended starting dosage is 2.5 mg 1 time a day, stable angina pectoris Adults: The dosage is always determined individually. The treatment starts with a dose of 5 mg 1 time per day, if necessary, can be increased to 10 mg dose one time per day. The maximum daily dose is 20 mg once a day one. The preparation  may be used in combination with beta-blockers, angiotensin-converting enzyme  inhibitor or a diuretic. Combination therapy usually increases the hypotensive effect of the drug. It is necessary to guard against the development of arterial hypotension. In patients with severe impaired hepatic function should be reduced therapeutic dose. In patients with impaired renal function The pharmacokinetics of the drug were not significantly changed.

 

Side effects:
As the application of other blockers “slow” calcium channels, the drug can cause facial flushing, headache, palpitations, dizziness and fatigue. These reactions are reversible and often occur early in treatment or increasing dose. Also, in a dose dependent peripheral edema may occur that result precapillary vasodilation. Patients with gum disease, or it may be easy peridontitom swelling of the gums. This can prevent the careful observance of oral hygiene.
In some cases: For the skin : rarely – urticaria, and itching. In isolated cases, photosensitivity reactions; From the test suspension results musculoskeletal system : in rare cases – arthralgia, myalgia; On the part of the central and peripheral nervous system: headache, dizziness. In rare cases, paresthesia; the part of the digestive system : rarely – nausea, gingival hyperplasia; increased activity of “liver” enzymes. Since the cardiovascular system : rarely tachycardia, palpitations, peripheral edema; Other : rarely fatigue, in isolated cases – hypersensitivity reactions, such as angioedema.