test suspension

Symptoms: marked reduction of blood pressure, bradycardia. Treatment: symptomatic therapy. In marked decrease in blood pressure patient should be given a horizontal position, lift test suspensionthe leg. With the development of bradycardia is shown in \ intravenous atropine at a dose of 0.5-1 mg. If this is insufficient, it is necessary to increase the volume of blood plasma by infusion dextrose (glucose), sodium chloride or dextran. Symptomatic drugs with predominant effect on the alpha-adrenergic receptors is prescribed for the ineffectiveness of these measures.

The interaction with other drugs
Felodipine increases the concentration of digoxin in plasma, but changes dosage of felodipine is required.
Inhibitors of cytochrome  (eg cimetidine, erythromycin, itraconazole, ketoconazole) slow felodipine metabolism in liver, increasing the plasma concentration of the drug.
Inductors microsomal enzymes (phenytoin, karbazepin, rifampicin, barbiturates) reduce the concentration of felodipine in plasma.
Nonsteroidal anti-inflammatory drugs do not weaken felodipine hypotensive effect.
a high degree of felodipine being associated with proteins not affect the bondability free fraction of other drugs (e.g., warfarin). Do not use test suspensiontogether with grapefruit juice due to it being in flavonoids which enhances the bioavailability of felodipine. Beta-blockers, verapamil, tricyclic antidepressants and diuretics enhance the hypotensive .

SPECIFIC NOTES
drug FELODIP, as well as other vasodilators, in rare cases can cause significant hypotension, which in a number of susceptible patients can lead to myocardial ischemia. Currently there is no data on the appropriateness of drug as a secondary prevention of myocardial infarction. Test suspension effective and well tolerated by patients, regardless of gender and age, as well as patients with concomitant diseases such as asthma and other lung diseases; impairment of renal function; diabetes; gout; hyperlipidemia; Raynaud’s syndrome, and after lung transplantation. Effect on the blood concentration of glucose and the lipid profile. Effects on ability to drive vehicles and management mechanisms: patients who during treatment with felodipine weakness observed, dizziness, should abandon the vehicle driving and work that requires attention and concentration.

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